FIGURE

Figure 1.

ID

ZDB-FIG-210512-28

Publication

Zhang et al., 2021 - Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency

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Figure 1.

Heart development defects in zebrafish. (A) Whole-mount in situ hybridization (WISH) analysis of mto1 expression on wild type larval zebrafish at various ages (2-cell to 24 hpf). (B) WISH analysis of mto1 on wild type larval zebrafish at 48 hpf and 72 hpf. cmlc2 marker was used to indicate the place of heart. Insets show higher magnifications of heart. (C) Tg (cmlc2:egfp) embryos at 2 dpf shows the heart-restricted GFP expression in both chambers. Scale bars: 50 μm. (D) WISH against cmlc2. According to the looping state, measured by the angles between ventricle and atrium, hearts were divided into normal (α < 90°), medium (90° < α < 180°), and severe (α > 180°). Scale bars: 50 μm. (E) The proportions of each phenotypes in the embryos in mutant and WT zebrafish.

Expression Data

Genes:	mto1 myl7
Fish:	AB
Anatomical Terms:	brain heart whole organism
Stage Range:	2-cell to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mto1^{zf3385/zf3385} (AB)
Observed In:	heart looping
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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