Gene

mto1

ID
ZDB-GENE-070209-253
Name
mitochondrial tRNA translation optimization 1
Symbol
mto1 Nomenclature History
Previous Names
  • zgc:158782
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from Zhang et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mto1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 10 Alliance Combined oxidative phosphorylation deficiency 10 614702
Associated With mto1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020595 MnmG-related, conserved site
Domain IPR026904 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal
Domain IPR040131 MnmG, N-terminal domain
Domain IPR047001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain
Domain IPR049312 tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal, N-terninal subdomain
Family IPR002218 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related
Family IPR004416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Homologous_superfamily IPR044920 tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain superfamily
Domain Details Per Protein
Protein Length FAD/NAD(P)-binding domain superfamily MnmG, N-terminal domain MnmG-related, conserved site tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal, N-terninal subdomain tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain superfamily tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related
UniProtKB:A0A8M9QE21 570
UniProtKB:A0A8M3B787 695
UniProtKB:A2RV35 659
UniProtKB:F1R509 659
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mto1-201 (1) Ensembl 2,185 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations