Gene
mto1
- ID
- ZDB-GENE-070209-253
- Name
- mitochondrial tRNA translation optimization 1
- Symbol
- mto1 Nomenclature History
- Previous Names
-
- zgc:158782
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Zhang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 10 | Alliance | Combined oxidative phosphorylation deficiency 10 | 614702 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020595 | MnmG-related, conserved site |
| Domain | IPR026904 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal |
| Domain | IPR040131 | MnmG, N-terminal domain |
| Domain | IPR047001 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain |
| Domain | IPR049312 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal, N-terninal subdomain |
| Family | IPR002218 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related |
| Family | IPR004416 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR044920 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain superfamily |
Domain Details Per Protein
| Protein | Length | FAD/NAD(P)-binding domain superfamily | MnmG, N-terminal domain | MnmG-related, conserved site | tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal, N-terninal subdomain | tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain | tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain superfamily | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QE21
|
570 | |||||||||
|
UniProtKB:A0A8M3B787
|
695 | |||||||||
|
UniProtKB:A2RV35
|
659 | |||||||||
|
UniProtKB:F1R509
|
659 |
Interactions and Pathways
No data available
Plasmids
No data available