FIGURE
Fig. 3
- ID
- ZDB-FIG-201111-24
- Publication
- Kim et al., 2019 - Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span
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Fig. 3
Quantitative RT-PCR and western blot analysis. Samples were prepared from (A, C) 4-dpf whole embryos, and (B, D) internal organs from 3-month-old zebrafish. Data are means, and bars indicate standard error. (A, B) Quantitative RT-PCR showed higher upregulation of inflammation-related genes in Sirt1-/- than in controls. (C, D) Western blot hybridization showed upregulation of IL-1b, active-caspase 3 and TGF-β. Control, wildtype; IL-1b, 18kDa; caspase 3a, 29 and 31 kDa; TGF-β, 45 kDa; β–actin, 43 kDa. *P < 0.05 versus control. |
Expression Data
| Genes: | |
|---|---|
| Fish: | |
| Anatomical Term: | |
| Stage Range: | Day 4 to Adult |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage Range: | Day 4 to Adult |
Phenotype Detail
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