FIGURE
Fig. 1
- ID
- ZDB-FIG-201111-23
- Publication
- Kim et al., 2019 - Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span
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Fig. 1
Sirt1 Knockout by Crispr/Cas9 technique. (A) Schematic illustration of the Sirt1 locus. Exon 1 of the Sirt1 gene was targeted. The CRISPR target site and PAM motif are indicated. (B) Sequence confirmation of four-nucleotide insertion mutations. (C) Predicted truncation of the SIRT1 protein. (D) Expression of the Sirt1 mutant was verified by western blot using an antibody of Sirt1; β-actin was used as a loading control. |
Expression Data
| Gene: | |
|---|---|
| Fish: | |
| Anatomical Term: | |
| Stage: | Day 4 |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage: | Day 4 |
Phenotype Detail
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Full text @ PLoS One