Gene
il1b
- ID
- ZDB-GENE-040702-2
- Name
- interleukin 1, beta
- Symbol
- il1b Nomenclature History
- Previous Names
-
- zgc:111873
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including fin regeneration; leukocyte chemotaxis; and response to bacterium. Predicted to be located in cytosol; extracellular region; and lysosome. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; heart; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to several human genes including IL1B (interleukin 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 310 figures from 228 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu384 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq175 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| phk2 | Allele with one deletion | Unknown | Unknown | TALEN | |
| sa16617 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21819 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31807 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sh446 | Allele with one deletion | Exon 4 | Frameshift, Premature Stop | CRISPR | |
| vu704 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| vu705 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| stomach cancer | Alliance | {Gastric cancer risk after H. pylori infection} | 613659 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Interleukin-1 conserved site | Interleukin-1 family |
|---|---|---|---|---|
|
UniProtKB:E6N152
|
272 | |||
|
UniProtKB:A0A8M1PI54
|
284 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Brenet, A., Somkhit, J., Csaba, Z., Ciura, S., Kabashi, E., Yanicostas, C., Soussi-Yanicostas, N. (2024) Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome. Cells. 13(8):
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Ding, H., Chen, X.C., Wan, L., Zhang, Y.Y., Rui, X.H., He, T., Liu, J., Shang, Z.B. (2024) Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues. Heliyon. 10:e30829e30829
- Karimi, Z., Zarifkar, A., Mirzaei, E., Dianatpour, M., Dara, M., Aligholi, H. (2024) Therapeutic effects of nanosilibinin in valproic acid-zebrafish model of autism spectrum disorder: Focusing on Wnt signaling pathway and autism spectrum disorder-related cytokines. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 84(5):454-468
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Lee, A., Kim, S.Y., Kang, S., Kang, S.H., Kim, D.W., Choe, J.W., Hyun, J.J., Jung, S.W., Jung, Y.K., Koo, J.S., Yim, H.J., Kim, S. (2024) Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 25(7):
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
- Li, L., He, Y.L., Xu, N., Wang, X.F., Song, B., Tang, B.Q., Lee, S.M. (2024) A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Redox Biology. 70:103057103057
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
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