FIGURE

Figure 9.

ID

ZDB-FIG-200829-71

Publication

Liu et al., 2020 - TMEM216 Deletion Causes Mislocalization of Cone Opsin and Rhodopsin and Photoreceptor Degeneration in Zebrafish

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Figure 9.

tmem216 knockouts exhibit abnormal outer segment disc morphology. Eyes from 7-dpf wildtype and tmem216^snyR8Δ60 zebrafish were processed for transmission EM. (A–D) Wildtype retina. Note that the outer segments with uniform discs. (E–I) tmem216^snyR8Δ60 homozygous retina. Although photoreceptors in the tmem216^snyR8Δ60 homozygous retina elaborated cilia (asterisk in F), the outer segments of these photoreceptors exhibit multiple defects. Abnormalities manifested as large vacuoles within the outer segment (asterisks in G and H), large vacuoles at the base of the outer segment (asterisks in I), shortened discs (arrows in G), abnormal disc morphology (arrowhead in G). Scale bar in I: 4 µm for A and E; 400 nm for B, D, and F; 200 nm for C, G, H, and I. BB, basal body; CP, ciliary pocket; IS, inner segment; OS, outer segment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tmem216^{zf3395/zf3395} (AB/TU)
Observed In:	eye photoreceptor cell photoreceptor disc membrane eye photoreceptor cell photoreceptor outer segment eye photoreceptor cell vacuole
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.