FIGURE

Figure 6.

ID

ZDB-FIG-200829-69

Publication

Liu et al., 2020 - TMEM216 Deletion Causes Mislocalization of Cone Opsin and Rhodopsin and Photoreceptor Degeneration in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 6.

Defective organization of F-actin in tmem216 knockout photoreceptors. Cryosections were immunostained with 4D2 (red). Some sections were stained with Phalloidin-RITC for F-actin (red). (A, C) 4D2 staining of wildtype and tmem216^snyΔ175 homozygous retina. 4D2 labels rod outer segments in the wildtype zebrafish (arrow in A); however, its reactivity was frequently mislocalized to the rod cell body in the knockouts (arrowheads in C). (B, D) Phalloidin staining in wildtype and tmem216^snyΔ175 homozygous retina. Vertically oriented F-actin in the wildtype (arrows in B) were disrupted in tmem216^snyΔ175 homozygous retina (arrowheads in D). Scale bar in H: 6 µm.

Expression Data

Antibody:	Ab5-rho
Fish:	AB/TU tmem216^{zf3394/zf3394} (AB/TU)
Anatomical Terms:	retinal rod cell cell body retinal rod cell rod photoreceptor outer segment
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tmem216^{zf3394/zf3394} (AB/TU)
Observed In:	photoreceptor cell filamentous actin retinal rod cell cell body
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.