FIGURE

Figure 11

ID

ZDB-FIG-200713-29

Publication

Coomer et al., 2020 - Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival

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Figure 11

Her9 mutant retinas display increased apoptosis beginning at 72 hpf. (A–D′) TUNEL staining on cryosections of WT and her9 mutant retinas.Her9 mutant embryos show no significant increase in cell death in the retina at 24 and 48 hpf compared to WT siblings (A–B′). At 72hpf, her9 mutant larvae display increased apoptosis in the GCL, INL, ONL and CMZ (C–C′) that remains elevated in the ONL at 5 dpf (D–D′). Cell counts of TUNEL+ cells (E–G). Note that the data points below the x-axis do not indicate negative numbers, but rather are an attempt by the ggplot2 package to display all the data points (ggplot2 in R: version 3.6.2; https://www.R-project.org/). ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer; L, lens. Scale bar = 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	her9^uky2/uky2
Observed In:	ciliary marginal zone apoptotic process retinal ganglion cell layer apoptotic process retinal inner nuclear layer apoptotic process retinal outer nuclear layer apoptotic process
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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