FIGURE

Fig. 3

ID

ZDB-FIG-171113-48

Publication

Kotb et al., 2016 - Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin

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Fig. 3

zApoL1 KD induces pericardial edema formation.

Zebrafish larvae (4 dpf) developed edema (arrow in A) after the KD of zApoL1 in contrast to CtrlMO and untreated larvae (B, C). Paraffin tissue sections of the larvae showed enlarged Bowman’s space (arrows in D) due to the knockdown of zApoL1 compared to CtrlMO and untreated larvae (E, F). g—glomerulus, m—myotome, i—intestine, y—yolk sac. Panel G shows that more than 70% of the larvae developed edema in response to KD of zApoL1. Data are means±SD of 4 experiments on a total of 100 larvae. Scale bars represent 500 μm (A-C) and 10 μm (D-F). We have used t-test for statistical analysis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO3-apol1
Knockdown Reagent:	MO3-apol1
Observed In:	heart pronephric capsular space pronephric glomerular capillary pronephric glomerulus morphogenesis
Stage:	Day 4

Phenotype Detail

Acknowledgments

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