FIGURE

Fig. 2

ID

ZDB-FIG-150929-2

Publication

Tsai et al., 2015 - Modulation of p53 and met expression by krüppel-like factor 8 regulates zebrafish cerebellar development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Up-regulation of p53 in the retinae and brain of klf8 morphants can be rescued by co-injection with klf8 mRNA. (A–E, G–J) Dorsal views of embryos. Enhanced p53 expression was detected in embryos injected with klf8-MO1^atg (C) or klf8-MO2^atg (D), or co-injected with klf8-MO^AC and klf8-MO^DO (E), but not in WT (A) or klf8-4mmMO1-injected (B) embryos at 24 hpf. (F) Percentage of klf8 morphants and control embryos displaying enhanced p53 expression. The increase in p53 expression in klf8 morphants (H) as compared to WT (G) was rescued by co-injection with different amounts of klf8 mRNA (J), but not with LacZ mRNA (I). (K) Percentage of klf8 morphants co-injected with klf8 mRNA or LacZ mRNA displaying enhanced p53 expression. Significance was determined using Student′s t-test. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars indicate standard errors.

Expression Data

Gene:	tp53
Fish:	WT + MO1-klf8 WT + MO2-klf8 WT + MO3-klf8 + MO4-klf8
Knockdown Reagents:	MO1-klf8 MO2-klf8 MO3-klf8 MO4-klf8
Anatomical Terms:	brain optic cup
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Neurobiol.