Gene
tp53
- ID
- ZDB-GENE-990415-270
- Name
- tumor protein p53
- Symbol
- tp53 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of nucleobase-containing compound metabolic process; and signal transduction by p53 class mediator. Localizes to chromatin. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Orthologous to human TP53 (tumor protein p53).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 222 figures from 181 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111919 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 54 figures from 39 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
adrenocortical carcinoma | Alliance | {Adrenocortical carcinoma, pediatric} | 202300 |
breast cancer | Alliance | Breast cancer, somatic | 114480 |
choroid plexus papilloma | Alliance | {Choroid plexus papilloma} | 260500 |
colorectal cancer | Alliance | {Colorectal cancer} | 114500 |
hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
Li-Fraumeni syndrome 1 | Alliance | Li-Fraumeni syndrome | 151623 |
nasopharynx carcinoma | Alliance | Nasopharyngeal carcinoma, somatic | 607107 |
osteosarcoma | Alliance | {Osteosarcoma} | 259500 |
pancreatic carcinoma | Alliance | Pancreatic cancer, somatic | 260350 |
Bone marrow failure syndrome 5 | 618165 | ||
{Basal cell carcinoma 7} | 614740 | ||
{Glioma susceptibility 1} | 137800 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR010991 | p53, tetramerisation domain |
Domain | IPR011615 | p53, DNA-binding domain |
Family | IPR002117 | p53 tumour suppressor family |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR036674 | p53-like tetramerisation domain superfamily |
Domain Details Per Protein
Protein | Length | p53, DNA-binding domain | p53-like tetramerisation domain superfamily | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | p53, tetramerisation domain | p53 tumour suppressor family |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BCD8
|
370 | ||||||
UniProtKB:A0A8M2BCE6
|
257 | ||||||
UniProtKB:B0R0M3
|
369 | ||||||
UniProtKB:P79734
|
373 | ||||||
UniProtKB:A0A0B4VFS7
|
261 | ||||||
UniProtKB:G1K2L5
|
374 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
tp53-201
(1)
|
Ensembl | 2211 nt | |
mRNA |
tp53-203
(1)
|
Havana | 2204 nt | |
mRNA |
tp53-206
(1)
|
Ensembl | 2208 nt | |
mRNA |
tp53-207
(1)
|
Ensembl | 1195 nt | |
mRNA |
tp53-208
(1)
|
Ensembl | 1956 nt | |
ncRNA |
tp53-002
(1)
|
Havana | 802 nt | |
ncRNA |
tp53-003
(1)
|
Havana | 579 nt | |
ncRNA |
tp53-004
(1)
|
Havana | 748 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-tp53 | monoclonal | Mouse |
|
3 | |||
Ab10-tp53 | monoclonal | Mouse |
|
9 | |||
Ab11-tp53 | monoclonal | IgG | Mouse |
|
Abcam plc
|
15 | |
Ab2-tp53 | monoclonal | IgG1 | Mouse |
|
3 | ||
Ab6-tp53 | monoclonal | Mouse |
|
2 | |||
Ab7-tp53 | polyclonal | Rabbit |
|
AnaSpec
|
9 | ||
Ab3-tp53 | monoclonal | IgG1 | Mouse |
|
6 | ||
Ab4-tp53 | polyclonal | Rabbit |
|
1 | |||
Ab9-tp53 | polyclonal | Rabbit |
|
1 |
Plasmids