FIGURE

Fig. S11

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ZDB-FIG-150313-16

Publication

Casari et al., 2014 - A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development

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Fig. S11

In vivo blocking of Smad3/TGFβ signaling impairs neuronal differentiation during early larval development. Confocal Z-stack images of the trunk of 72 hpf transgenic embryos expressing GFP under control of either a glial or neuronal promoter: ngn1, neuroD and mnx1. All these transgenic lines have been treated at 24 hpf with Alk5-inhibitor LY364947 and confocal observation performed after two days of treatment. Disturbing Smad3/TGFβ signaling at early larval development causes an increase of proliferative cells (ngn1), decrease of differentiating cells (neuroD) and reduction of late differentiating motor neurons (mnx1).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Biology, 396(1), Casari, A., Schiavone, M., Facchinello, N., Vettori, A., Meyer, D., Tiso, N., Moro, E., Argenton, F., A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development, 81-93, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.