FIGURE

Fig. 8

ID

ZDB-FIG-140811-44

Publication

Zhu et al., 2014 - Haploinsufficiency of Def Activates p53-Dependent TGFbeta Signalling and Causes Scar Formation after Partial Hepatectomy

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Fig. 8

Def haploinsufficiency caused an altered migration behaviour of leukocytes in def^+/- fish that was rescued by treatment with Dex or ectopic expression of Def in hepatocytes.

(A–H) Representative images of co-immunostaining of EGFP (green, label macrophage), dsRed (yellow, label neutrophil) and Bhmt (red) in the wound epidermis in wild-type (A,B), def^+/- (C,D), def^+/- treated with Dex (E,F) and def^+/-Tg(fabp10a:def) progeny (G,H) 12 and 36 h after PH, respectively. All are in the background of Tg(coro1a:eGFP;lyz:dsRED). Nuclei were stained with DAPI (blue). In each case, more than 10 sections from at least three wild-type or def^+/- mutant fish were examined. bc, blood clot; lv, liver tissue. Scale bars: 150 μm (A–H).

Expression Data

Genes:	DsRed2 EGFP
Antibody:	Ab1-bhmt
Fish:	hkz04tTg; nz50Tg utp25^hi429Tg/+; hkz04tTg; nz50Tg utp25^hi429Tg/+; hkz04tTg; nz50Tg; zju21Tg
Condition:	physical alteration: anatomical structure
Anatomical Terms:	hepatocyte macrophage neutrophil
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	utp25^hi429Tg/+; hkz04tTg; nz50Tg
Condition:	physical alteration: anatomical structure
Observed In:	inflammatory response to wounding
Stage:	Adult

Phenotype Detail

Acknowledgments

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