FIGURE

Fig. 5

ID

ZDB-FIG-140512-4

Publication

Xu et al., 2014 - Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium

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Fig. 5

Gβ1 signaling regulates protrusive activity in the leading region of the pLLP. (A, B) Snapshots of the leading region of the pLLP from 30-min confocal time-lapse movies of control (A) or gnb1a/b MO1-injected (B) Tg(-8.0cldnb:lynEGFP) embryos, at 30 hpf, using a 40×/NA 1.3 objective (Movies 7 and 8). White arrows, protrusions at the leading edge of the pLLP. (C, D) Number of protrusions per cell (C) and average length of the filopodia (D) at the leading edge of the pLLP, in control or gnb1a/b MO1-injected embryos. *, p<0.01 vs. control.

Expression Data

Gene:	EGFP
Fish:	zf106Tg zf106Tg + MO2-gnb1a + MO2-gnb1b + MO4-tp53
Knockdown Reagents:	MO2-gnb1a MO2-gnb1b MO4-tp53
Anatomical Term:	posterior lateral line primordium
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf106Tg + MO2-gnb1a + MO2-gnb1b + MO4-tp53
Knockdown Reagents:	MO2-gnb1a MO2-gnb1b MO4-tp53
Observed In:	cell cell projection posterior lateral line primordium posterior lateral line primordium filopodium
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 385(2), Xu, H., Ye, D., Behra, M., Burgess, S., Chen, S., and Lin, F., Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium, 316-27, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.