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Fig. 5
Gβ1 signaling regulates protrusive activity in the leading region of the pLLP. (A, B) Snapshots of the leading region of the pLLP from 30-min confocal time-lapse movies of control (A) or gnb1a/b MO1-injected (B) Tg(-8.0cldnb:lynEGFP) embryos, at 30 hpf, using a 40×/NA 1.3 objective (Movies 7 and 8). White arrows, protrusions at the leading edge of the pLLP. (C, D) Number of protrusions per cell (C) and average length of the filopodia (D) at the leading edge of the pLLP, in control or gnb1a/b MO1-injected embryos. *, p<0.01 vs. control.
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Reprinted from Developmental Biology, 385(2), Xu, H., Ye, D., Behra, M., Burgess, S., Chen, S., and Lin, F., Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium, 316-27, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.