FIGURE
Fig. S1
- ID
- ZDB-FIG-130318-3
- Publication
- Eisa-Beygi et al., 2013 - The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. S1
Inhibition of HMGCR is associated with clusters of abnormally dilated cerebral vessels in the forebrain and hindbrain. (A, B) Representative photomicrographs of Tg(fli1:EGFP) embryos exposed to DMSO or 0.5 mg/L ATV and imaged at 28 hpf. White asterisks indicate abnormally dilated PPrA and PMBC. Anterior is to the left and dorsal to the top. Scale bar = 40 μm. (C, D) 2D quantification of 28 hpf zebrafish cerebral vessel diameters. Data are presented as the mean and standard error of the mean. N = 11, p = 0.002 (C) and p < 0.001 (D). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Reprinted from Developmental Biology, 373(2), Eisa-Beygi, S., Hatch, G., Noble, S., Ekker, M., and Moon, T.W., The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway, 258-266, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.