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Fig. S1 Inhibition of HMGCR is associated with clusters of abnormally dilated cerebral vessels in the forebrain and hindbrain. (A, B) Representative photomicrographs of Tg(fli1:EGFP) embryos exposed to DMSO or 0.5 mg/L ATV and imaged at 28 hpf. White asterisks indicate abnormally dilated PPrA and PMBC. Anterior is to the left and dorsal to the top. Scale bar = 40 μm. (C, D) 2D quantification of 28 hpf zebrafish cerebral vessel diameters. Data are presented as the mean and standard error of the mean. N = 11, p = 0.002 (C) and p < 0.001 (D).
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Reprinted from Developmental Biology, 373(2), Eisa-Beygi, S., Hatch, G., Noble, S., Ekker, M., and Moon, T.W., The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway, 258-266, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.