FIGURE

Fig. 4

ID

ZDB-FIG-121212-27

Publication

Lane et al., 2012 - Otx but not mitf transcription factors are required for zebrafish retinal pigment epithelium development

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Fig. 4

Otx knockdown causes a decrease in dct expression in the developing RPE.

dopachrome tautomerase (dct) mRNA expression was analyzed through in situ hybridization at 24 hpf in otx morphants. dct expression was reduced only in the ventral most region of the optic cup in single morphants (B–D, white arrows) compared to controls (A). dct expression was significantly decreased in the ventral RPE of otx1a/otx2 morphants and to an even greater degree in otx1a/otx1b/otx2 morphants (E–F, white arrows). dct expression in neural crest melanocytes was unaffected (black arrows). Approximately 50 larvae were examined for each condition.

Expression Data

Gene:	dct
Fish:	WT WT + MO1-otx1 WT + MO1-otx2a WT + MO1-otx2b WT + MO1-otx2a + MO1-otx2b WT + MO1-otx1 + MO1-otx2a + MO1-otx2b
Knockdown Reagents:	MO1-otx1 MO1-otx2a MO1-otx2b
Anatomical Terms:	neural crest melanocyte optic cup ventral-most region
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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