FIGURE

Fig. S3

ID

ZDB-FIG-121205-3

Publication

Blaker-Lee et al., 2012 - Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes

Other Figures

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Fig. S3

Pigmentation is abnormal in LOF embryos. Pigment cells were observed after LOF, at 48 hpf, by brightfield imaging. Rostral and midline cells were specifically scored as a measure of normal melanocyte migration. (A-I) dorsal views. Genes targeted for LOF by MO injection are indicated above each set of panels. Red arrowhead, no rostral pigment cells; red arrow, no midline pigment cells; scale bar, 150 μM. Average of 35 embryos assayed per gene, over 2-4 independent experiments, 70-100% affected compared to control MO-injected embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-aldoaa WT + MO1-coro1a WT + MO1-gdpd3a WT + MO1-hirip3 WT + MO1-ino80e WT + MO1-tlcd3ba WT + MO5-mapk3 WT + MO5-ppp4ca (all 8)
Knockdown Reagents:	MO1-aldoaa MO1-coro1a MO1-gdpd3a MO1-hirip3 MO1-ino80e MO1-tlcd3ba MO5-mapk3 MO5-ppp4ca (all 8)
Observed In:	pigment cell
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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