FIGURE

Fig. 4

ID

ZDB-FIG-111028-28

Publication

Dalgin et al., 2011 - Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas

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Fig. 4

Mnx1-deficient embryos lack beta cells but gain alpha cells. (A-H) Confocal images of the dorsal pancreatic bud at 30 hpf showing double FISH for (A-D) ins (green) and somatostatin (sst1, red) or (E-H) ins (green) and glucagon (gcga, red) in zebrafish embryos that were uninjected (A,E) or injected with control MO (B,F), Mnx1 MO1 (C,G) or Mnx1 MO2 (D,H). (I) Mean (± s.d.) number of cells expressing the three markers. ^*, P<0.001 (t-test, two-tailed distribution, Bonferroni correction). Results are from three independent experiments with a minimum of ten embryos per group. CoMO, control MO.

Expression Data

Genes:	gcga ins sst1.1
Fish:	AB AB + MO1-mnx1 AB + MO2-mnx1
Knockdown Reagents:	MO1-mnx1 MO2-mnx1
Anatomical Terms:	posterior pancreatic bud D cell posterior pancreatic bud pancreatic A cell posterior pancreatic bud pancreatic B cell
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-mnx1 AB + MO2-mnx1
Knockdown Reagents:	MO1-mnx1 MO2-mnx1
Observed In:	D cell pancreatic A cell pancreatic A cell differentiation pancreatic B cell posterior pancreatic bud type B pancreatic cell differentiation (all 6)
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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