Gene
sst1.1
- ID
- ZDB-GENE-030131-4743
- Name
- somatostatin 1, tandem duplicate 1
- Symbol
- sst1.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Predicted to be involved in regulation of cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in endocrine system; hypoblast; nervous system; and spleen. Orthologous to human SST (somatostatin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92779 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| icm40 | Allele with one delins | Exon 1 | Frameshift | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Somatostatin | Somatostatin/Cortistatin, C-terminal |
|---|---|---|---|
|
UniProtKB:Q8JHX5
|
114 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sst1.1-201
(1)
|
Ensembl | 693 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-29L4 | ZFIN Curated Data | |
| Encodes | EST | cegs2544 | Rauch et al., 2003 | |
| Encodes | EST | fd57e04 | ||
| Encodes | cDNA | MGC:92779 | ZFIN Curated Data |
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- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Spikol, E.D., Cheng, J., Macurak, M., Subedi, A., Halpern, M.E. (2024) Genetically defined nucleus incertus neurons differ in connectivity and function. eLIFE. 12:
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142eadf5142
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Shin, M., Yin, H.M., Shih, Y.H., Nozaki, T., Portman, D., Toles, B., Kolb, A., Luk, K., Isogai, S., Ishida, K., Hanasaka, T., Parsons, M.J., Wolfe, S.A., Burns, C.E., Burns, C.G., Lawson, N.D. (2023) Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Developmental Cell. 58(22):2614-2626.e7
- Carril Pardo, C.A., Massoz, L., Dupont, M.A., Bergemann, D., Bourdouxhe, J., Lavergne, A., Tarifeño-Saldivia, E., Helker, C.S., Stainier, D.Y., Peers, B., Voz, M.M., Manfroid, I. (2022) A δ-cell subpopulation with pro-β cell identity contributes to efficient age-independent recovery in a zebrafish diabetes model. eLIFE. 11:
- Singh, S.P., Chawla, P., Hnatiuk, A., Kamel, M., Silva, L.D., Spanjaard, B., Eski, S.E., Janjuha, S., Olivares-Chauvet, P., Kayisoglu, O., Rost, F., Bläsche, J., Kränkel, A., Petzold, A., Kurth, T., Reinhardt, S., Junker, J.P., Ninov, N. (2022) A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish. Development (Cambridge, England). 149(2)
- Zhao, T., Ye, Z., Liu, Y., Lin, H., Li, S., Zhang, Y. (2022) Mutation of spexin2 promotes feeding, somatic growth, adiposity and insulin resistance in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 322(5):R454-R465
- Dalgin, G., Prince, V.E. (2020) Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Developmental Biology. 471:1-9
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