FIGURE

Fig. 7

ID

ZDB-FIG-111028-31

Publication

Dalgin et al., 2011 - Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas

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Fig. 7

Mnx1 knockdown alters the alpha:beta cell ratio in a similar fashion in control and RA-treated embryos. (A-F) Confocal images of DMSO carrier-treated (A,C,E) and RA-treated (B,D,F) 30 hpf zebrafish embryos that were injected with control MO (A,B), Mnx1 MO1 (C,D) or Mnx1 MO2 (E,F), showing double FISH for ins (green) and gcga (red). Arrows indicate beta cells and arrowheads indicate alpha cells. (G) Mean (± s.d.) number of alpha and beta cells from four independent experiments with a minimum of 45 embryos per group. Anterior to left.

Expression Data

Genes:	gcga ins
Fish:	AB AB + MO1-mnx1 AB + MO2-mnx1
Condition:	chemical treatment: all-trans-retinoic acid
Knockdown Reagents:	MO1-mnx1 MO2-mnx1
Anatomical Terms:	posterior pancreatic bud pancreatic A cell posterior pancreatic bud pancreatic B cell
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-mnx1 AB + MO2-mnx1
Condition:	chemical treatment: all-trans-retinoic acid
Knockdown Reagents:	MO1-mnx1 MO2-mnx1
Observed In:	endocrine pancreas development pancreatic A cell pancreatic A cell differentiation pancreatic B cell posterior pancreatic bud retinoic acid receptor signaling pathway type B pancreatic cell differentiation
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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