FIGURE

Fig. 2

ID

ZDB-FIG-111018-19

Publication

Mouillesseaux et al., 2011 - Mutation in utp15 Disrupts Vascular Patterning in a p53-Dependent Manner in Zebrafish Embryos

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Fig. 2

Aberrant expression of arterial and venous endothelial cell markers in LA1908 mutant embryos.

A–B, Expression of grl, an arterial EC marker, was dramatically reduced in LA1908 mutant embryos (B versus A) at 21 hpf. C–D, Expression of the venous marker, flt4, was increased and localized ectopically in LA1908 mutant embryos at 27 hpf (D versus C). Vertical black bars, approximate location of vibratome cross-sections shown in C′–D′. C′–D′, Vibratome cross-section of embryos shown in C, D, revealing flt4 expression was appropriately restricted to the CV in 27 hpf wildtype embryos (C′), but is ectopically expressed in the DA and ISVs in LA1908 mutant embryos (D′). Embryos shown are representative from triplicate experiments performed on a minimum of 5 embryos per condition.

Expression Data

Genes:	flt4 hey2
Fish:	la116Tg utp15^{la1908/la1908}; la116Tg
Anatomical Terms:	dorsal aorta blood vessel endothelial cell intersegmental vessel posterior cardinal vein blood vessel endothelial cell vascular cord blood vessel endothelial cell
Stage Range:	20-25 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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