FIGURE

Fig. 4

ID
ZDB-FIG-101118-17
Publication
Shive et al., 2010 - brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis
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Fig. 4

brca2Q658X homozygotes are predisposed to testicular neoplasias, and brca2Q658X and tp53M214K mutations have collaborative effects on tumorigenesis. (A) Undifferentiated stromal cell tumor from a brca2Q658X homozygote. (B) Undifferentiated stromal cell tumor from a brca2Q658X homozygote with irregular bundles around poorly defined small tubular structures (Inset). (C) Papillary cystadenoma from a brca2Q658X homozygote. (D) Seminoma from a brca2Q658X homozygote. (E) Age at tumor onset is significantly lower in both brca2Q658X homozygous;tp53M214K homozygous zebrafish and brca2Q658X heterozygous;tp53M214K homozygous zebrafish compared with the tp53M214K homozygous zebrafish parent line. (F) The ovary is a primary site for tumor development in brca2Q658X heterozygous;tp53M214K homozygous zebrafish, with oocyte entrapment (Inset). oc, oocyte; cr, cranial; d, dorsal; v, ventral; sb, swim bladder. (Scale bars: 100 μm in A and B; 200 μm in C and D; 1,000 μm in F; 50 μm in the Insets in A, B, C, and D; 100 μm in the Inset in F.)

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA