ZFIN Image: Shive et al., 2010, Fig. 4

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Figure Caption

Fig. 4

brca2^Q658X homozygotes are predisposed to testicular neoplasias, and brca2^Q658X and tp53^M214K mutations have collaborative effects on tumorigenesis. (A) Undifferentiated stromal cell tumor from a brca2^Q658X homozygote. (B) Undifferentiated stromal cell tumor from a brca2^Q658X homozygote with irregular bundles around poorly defined small tubular structures (Inset). (C) Papillary cystadenoma from a brca2^Q658X homozygote. (D) Seminoma from a brca2^Q658X homozygote. (E) Age at tumor onset is significantly lower in both brca2^Q658X homozygous;tp53^M214K homozygous zebrafish and brca2^Q658X heterozygous;tp53^M214K homozygous zebrafish compared with the tp53^M214K homozygous zebrafish parent line. (F) The ovary is a primary site for tumor development in brca2^Q658X heterozygous;tp53^M214K homozygous zebrafish, with oocyte entrapment (Inset). oc, oocyte; cr, cranial; d, dorsal; v, ventral; sb, swim bladder. (Scale bars: 100 μm in A and B; 200 μm in C and D; 1,000 μm in F; 50 μm in the Insets in A, B, C, and D; 100 μm in the Inset in F.)

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA