FIGURE

Fig. 4

ID

ZDB-FIG-101007-6

Publication

Ramesh et al., 2010 - A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

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Fig. 4

Contractile muscle properties of G93R mutant fish are intact, but the response to repeated stimulation is significantly altered. (A) Muscles of G93R mutant fish are capable of producing similar maximum twitch force as nTg siblings (n=9 per genotype, P=0.816). (B) When subjected to repeated 4 ms stimuli at 0.2 Hz, the muscles of G93R mutant fish fatigue more slowly than those of nTg siblings. The average of the percentage of maximum force achieved (CSA dimension) is plotted against time and linear regression applied to the data (n=8 per genotype). (C) The slope values of linear regression of the percentage of maximal force achieved versus time in response to repeated stimulation were significantly different. G93R mutant fish are able to maintain significantly larger forces for a longer period of time in comparison to nTg sibling controls (n=8 per genotype, P=0.018).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os10Tg
Observed In:	skeletal muscle contraction
Stage:	Adult

Phenotype Detail

Acknowledgments

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Full text @ Dis. Model. Mech.