FIGURE

Fig. 3

ID

ZDB-FIG-101007-5

Publication

Ramesh et al., 2010 - A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

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Fig. 3

G93R mutant fish exhibit reduced endurance. (A) Ten-month-old adult WT os4 and nTg siblings were subjected to increasing current (4.1 cm/second steps) every 5 minutes until fatigue. Critical swimming speed (U_crit, cm/s), a measure of the velocity at which a fish can maintain swimming for a set period, was not significantly different between WT os4 and nTg siblings (n=5 nTg and n=9 WT os4). (B) U_crit values between G93R os10 adults and nTg controls were significantly different at 12 months of age (*P<0.0001, n=15 for each genotype). (C) Affected G93R os6 fish at 16 months of age cannot maintain swimming for as long as nTg controls (*P<0.001, n=10 nTg and n=8 G93R os6). (D) WT os3 fish are unaffected at 24 months of age in comparison to nTg fish (n=9 nTg and n=11 WT os3). Data are mean ± s.d.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os6Tg os10Tg
Observed In:	voluntary musculoskeletal movement
Stage:	Adult

Phenotype Detail

Acknowledgments

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Full text @ Dis. Model. Mech.