FIGURE

Fig. 2

ID

ZDB-FIG-101007-4

Publication

Ramesh et al., 2010 - A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

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Fig. 2

Abnormal NMJs are observed in larval and adult G93R os10 fish. (A) Whole-mount antibody labeling with synaptic vesicle 2 (SV2, red) for pre-synaptic vesicles and α-bungarotoxin (BTX, green) for post-synaptic terminals from nTg (top) and G93R os10 (bottom) 11-dpf larvae. (B) Quantitation of NMJ properties in larval (11 dpf) G93R os10 zebrafish in comparison to nTg controls. (C) Adult NMJs were examined in trunk sections by immunolabeling with antibodies to SV2 and α-BTX. (D) Quantitation of NMJ properties in adult (12 month) G93R os10 zebrafish and nTg controls (*P<0.02, n=10 sections from three larvae or adult fish per genotype). Bars, 20 μm.

Expression Data

Gene:	chrna1
Antibody:	Ab-SV2
Fish:	WT os10Tg
Anatomical Terms:	motor neuron synaptic vesicle skeletal muscle neuromuscular junction skeletal muscle cell acetylcholine-gated channel complex
Stage Range:	Days 7-13 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os10Tg
Observed In:	motor neuron terminal bouton skeletal muscle cell neuromuscular junction
Stage Range:	Days 7-13 to Adult

Phenotype Detail

Acknowledgments

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Full text @ Dis. Model. Mech.