FIGURE

Fig. 3

ID

ZDB-FIG-100225-20

Publication

Rai et al., 2010 - Dnmt3 and G9a cooperate for tissue-specific development in zebrafish

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Fig. 3

Dnmt3 morphants are defective in retinal differentiation. Whole mount in situ for pax6.2, crx, and neurod in dnmt3 and control morphants at 80 hpf. Whereas all the retinal cells expressed pax6.2, a marker of retinal progenitors, markers of specific progenitors (crx and neurod) were absent in dnmt3 morphants. These defects can be complemented by co-injection of the wild-type Dnmt3 (Dnmt3^WT) but not with the catalytically inactive Dnmt3 derivative (Dnmt3^C1240S).

Expression Data

Genes:	atoh7 crx neurod1 pax6b pcna
Fish:	WT WT + MO1-dnmt3bb.2 WT + MO4-dnmt1
Knockdown Reagents:	MO1-dnmt3bb.2 MO4-dnmt1
Anatomical Terms:	eye retina retinal ganglion cell retinal inner nuclear layer retinal photoreceptor layer
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dnmt3bb.2 WT + MO4-dnmt1
Knockdown Reagents:	MO1-dnmt3bb.2 MO4-dnmt1
Observed In:	camera-type eye photoreceptor cell differentiation retina photopic photoreceptor cell retina layer formation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Open Access.

Full text @ J. Biol. Chem.