Gene
pcna
- ID
- ZDB-GENE-000210-8
- Name
- proliferating cell nuclear antigen
- Symbol
- pcna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA polymerase processivity factor activity. Acts upstream of or within response to activity and response to bacterium. Located in nucleus. Is expressed in several structures, including anterior neural tube; head; immature eye; nervous system; and pleuroperitoneal region. Orthologous to human PCNA (proliferating cell nuclear antigen).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 154 figures from 92 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb16 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shin et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia-telangiectasia-like disorder-2 | Alliance | ?Ataxia-telangiectasia-like disorder 2 | 615919 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR022659 | Proliferating cell nuclear antigen, PCNA, conserved site |
| Domain | IPR022648 | Proliferating cell nuclear antigen, PCNA, N-terminal |
| Domain | IPR022649 | Proliferating cell nuclear antigen, PCNA, C-terminal |
| Family | IPR000730 | Proliferating cell nuclear antigen, PCNA |
| Homologous_superfamily | IPR046938 | DNA clamp superfamily |
Domain Details Per Protein
| Protein | Length | DNA clamp superfamily | Proliferating cell nuclear antigen, PCNA | Proliferating cell nuclear antigen, PCNA, conserved site | Proliferating cell nuclear antigen, PCNA, C-terminal | Proliferating cell nuclear antigen, PCNA, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9PTP1
|
260 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-pcna | monoclonal | IgG2a , k | Mouse |
|
Sigma-Aldrich
Santa Cruz Biotechnology, Inc. Millipore Dako North America, Inc. Life Technologies (Invitrogen) Cell Signaling Technology, Inc. Abcam plc Calbiochem Vector Laboratories |
359 | |
| Ab4-pcna | polyclonal | Rabbit |
|
Abcam plc
|
5 |
Plasmids
No data available