Gene
pcna
- ID
- ZDB-GENE-000210-8
- Name
- proliferating cell nuclear antigen
- Symbol
- pcna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have DNA polymerase processivity factor activity. Involved in response to activity and response to bacterium. Localizes to nucleus. Is expressed in several structures, including anterior neural tube; head; immature eye; nervous system; and pleuroperitoneal region. Orthologous to human PCNA (proliferating cell nuclear antigen).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 152 figures from 90 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb16 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shin et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia-telangiectasia-like disorder-2 | Alliance | ?Ataxia-telangiectasia-like disorder 2 | 615919 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR022659 | Proliferating cell nuclear antigen, PCNA, conserved site |
| Domain | IPR022648 | Proliferating cell nuclear antigen, PCNA, N-terminal |
| Domain | IPR022649 | Proliferating cell nuclear antigen, PCNA, C-terminal |
| Family | IPR000730 | Proliferating cell nuclear antigen, PCNA |
| Homologous_superfamily | IPR046938 | DNA clamp superfamily |
Domain Details Per Protein
| Protein | Length | DNA clamp superfamily | Proliferating cell nuclear antigen, PCNA | Proliferating cell nuclear antigen, PCNA, conserved site | Proliferating cell nuclear antigen, PCNA, C-terminal | Proliferating cell nuclear antigen, PCNA, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9PTP1
|
260 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-pcna | monoclonal | IgG2a , k | Mouse |
|
Sigma-Aldrich
Santa Cruz Biotechnology, Inc. Millipore Dako North America, Inc. Life Technologies (Invitrogen) Cell Signaling Technology, Inc. Abcam plc Calbiochem Vector Laboratories |
354 | |
| Ab4-pcna | polyclonal | Rabbit |
|
Abcam plc
|
5 |
Plasmids
No data available