FIGURE

Fig. 2

ID

ZDB-FIG-090831-37

Publication

French et al., 2009 - Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development

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Fig. 2

Morpholino inhibition of gdf6a results in aberrant expression of axon guidance molecules. The expression of efnb2a is found in the dorsal retina and lens (A) and is lost in the retina in gdf6a morphants. Expression in the lens is not affected (B). The expression of ephb2 and ephb3 is found in the ventral retina in wildtype animals (C, E), although the domain of epbb3 is more restricted compared to ephb2. The expression of ephb2 is expanded throughout the retina in gdf6a morphants (D), as is the expression of ephb3 (F), albeit to a lesser extent than ephb2. All embryos were staged to 28 hpf.

Expression Data

Genes:	efnb2a ephb2a ephb3a
Fish:	WT WT + MO1-gdf6a + MO4-tp53
Knockdown Reagents:	MO1-gdf6a MO4-tp53
Anatomical Terms:	optic cup optic cup dorsal region optic cup ventral region solid lens vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 333(1), French, C.R., Erickson, T., French, D.V., Pilgrim, D.B., and Waskiewicz, A.J., Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development, 37-47, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.