Fig. 2
- ID
- ZDB-FIG-090220-57
- Publication
- Devine et al., 2009 - A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary
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gli expression in the developing pituitary placode. (A, E, I) At 15 hpf (11 somites), gli1, gli2a and gli2b are all expressed in epidermal cells at the ANR of the embryo that will form the pituitary (arrows). (B, F, J) At 18 hpf (18 somites), gli1 gli2a, and gli2b expression all overlap with pitx3 expression (B inset) at the ANR. gli3 is expressed in adjacent neural ectoderm but not in the developing pituitary placode (F, inset). (C, G, K) At 21 hpf (24 somites) gli1, gli2a, and gli2b expression is continuous across the ANR and gli3 is still absent (G, inset). (D) At 30 hpf gli1 expression is maintained in the anterior region of the placode, the pars distalis (arrow), but is reduced in the posterior region, the pars intermedia (arrowhead).(H, L) At 30 hpf gli2a and gli2b are expressed posteriorly in the PI (arrowheads), but not in the pars distalis (arrows). (A–C, E–G, I–K) Dorsal views, anterior left. (D, H, L) Lateral views of the ventral forebrain, anterior to the left, eyes removed. Red dashed lines show border between developing placodal cells and neural ectoderm of the diencephalon. Scale bar: A–C, E–G, I–K; 100 μm, D, H, L; 30 μm. |
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| Stage Range: | 10-13 somites to Prim-15 |
Reprinted from Developmental Biology, 326(1), Devine, C.A., Sbrogna, J.L., Guner, B., Osgood, M., Shen, M.C., and Karlstrom, R.O., A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary, 143-154, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.