Gene
gli2a
- ID
- ZDB-GENE-990706-8
- Name
- GLI family zinc finger 2a
- Symbol
- gli2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including digestive tract morphogenesis; kidney development; and nervous system development. Located in non-motile cilium and nucleus. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and neural plate. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu801 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- 47 figures from 29 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| gli2a_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| i275 | Allele with one deletion | Unknown | Unknown | zinc finger nuclease | |
| i276 | Allele with one insertion | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
| la016571Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s406 | unknown | Unknown | Unknown | ENU | |
| sa10919 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12847 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15237 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21538 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Culler-Jones syndrome | Alliance | Culler-Jones syndrome | 615849 |
| holoprosencephaly 9 | Alliance | Holoprosencephaly 9 | 610829 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2H2-type zinc-finger protein GLI-like | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:Q9YGS4
|
1439 |
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Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-61D13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-25L23 | ZFIN Curated Data | |
| Encodes | EST | eu801 | Thisse et al., 2005 | |
| Encodes | EST | fc85b05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195099 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130967 (1) | 6070 nt | ||
| Genomic | GenBank:BX548071 (2) | 223099 nt | ||
| Polypeptide | UniProtKB:Q9YGS4 (1) | 1439 aa |
- Cuevas, M., Terhune, E., Wethey, C., James, M., Netsanet, R., Grofova, D., Monley, A., Hadley Miller, N. (2023) Cytoskeletal Keratins Are Overexpressed in a Zebrafish Model of Idiopathic Scoliosis. Genes. 14(5):
- Zhao, Y., Wang, H., He, T., Ma, B., Chen, G., Tzeng, C. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of cell communication and signaling. 17(4):1335-1354
- Burton, D.F., Boa-Amponsem, O.M., Dixon, M.S., Hopkins, M.J., Herbin, T.A., Toney, S., Tarpley, M., Rodriguez, B.V., Fish, E.W., Parnell, S.E., Cole, G.J., Williams, K.P. (2022) Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol-induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder. Journal of neuroscience research. 100(8):1585-1601
- Chen, X., Liu, F., Li, B., Wang, Y., Yuan, L., Yin, A., Chen, Q., Hu, W., Yao, Y., Zhang, M., Wu, Y., Chen, K. (2022) Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function. Cell & Bioscience. 12:103
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Thauvin, M., de Sousa, R.M., Alves, M., Volovitch, M., Vriz, S., Rampon, C. (2022) An early Shh-H2O2 reciprocal regulatory interaction controls the regenerative program during zebrafish fin regeneration. Journal of Cell Science. 135(6):
- Vacca, F., Gomes, A.S., Murashita, K., Cinquetti, R., Roseti, C., Barca, A., Rønnestad, I., Verri, T., Bossi, E. (2022) Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters. The Journal of physiology. 600(10):2377-2400
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Suzuki, T., Hirai, Y., Uehara, T., Ohga, R., Kosaki, K., Kawahara, A. (2021) Involvement of the zebrafish trrap gene in craniofacial development. Scientific Reports. 11:24166
- Wang, S., Zhou, Z., Li, J., Wang, Y., Li, H., Lv, R., Xu, G., Zhang, J., Bi, J., Huo, R. (2021) Identification of ACTA2 as a Key Contributor to Venous Malformation. Frontiers in cell and developmental biology. 9:755409
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