FIGURE

Fig. 1

ID

ZDB-FIG-080604-1

Publication

Postel et al., 2008 - Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex

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Fig. 1

Skeletal muscle detachments in loc/ilk mutant embryos. (A,B) Transmitted light images of tail regions in wt (A) and loc/ilk mutant embryos (B) at 4.5 dpf. Muscle fibre retractions are indicated with arrowheads. (C,D) Phalloidin staining and confocal images of wt sibling embryo (C) and of loc/ilk mutant embryo (D) at 4.5 dpf. Muscle fibre detachments are apparent in 50% of the loc/ilk mutant embryos (arrowheads). (E,F) α-actinin antibody staining of wt sibling (E) and loc/ilk mutant embryo (F) at 4.5 dpf. Regions of muscle fibre detachments are indicated by arrowheads. (G–J) Phalloidin staining and confocal images of uninjected control embryo (G), uninjected loc/ilk mutant embryo (H), dystroglycan MO injected wt embryo (I) and a dystroglycan MO injected loc/ilk mutant embryo (J). Tail regions of 2 dpf embryos are shown.

Expression Data

Antibody:	Ab1-actn
Fish:	WT ilk^hu801/hu801
Anatomical Term:	skeletal muscle cell sarcomere
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ilk^hu801/hu801 WT + MO1-dag1 ilk^hu801/hu801 + MO1-dag1
Knockdown Reagent:	MO1-dag1
Observed In:	muscle attachment post-vent region skeletal muscle cell skeletal muscle cell actin cytoskeleton trunk musculature skeletal muscle cell
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 318(1), Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J., Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex, 92-101, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.