FIGURE

Fig. 8

ID

ZDB-FIG-080114-37

Publication

Yeh et al., 2008 - AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression

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Fig. 8

AML1-ETO downregulates scl, leading to the early effects of AML1-ETO expression in primitive hematopoietic cells. (A) In situ hybridization of scl. AML1-ETO expression results in scl downregulation specifically in hematopoietic cells. The expression of scl in the head (asterisk), in the endothelial primordium (arrowhead), and in the posterior tail region (arrow) was not affected. (B) In situ hybridization of gata1, mpo and fluorescent images of zpu.1-EGFP transgenic zebrafish. Injections of scl mRNA restored gata1 expression and reversed pu.1 and mpo induction in Tg(hsp:AML1-ETO) embryos.

Expression Data

Genes:	gata1a mpx spi1b tal1
Fish:	WT f3Tg f3Tg; zdf11Tg
Condition:	heat shock
Anatomical Terms:	granulocyte granulocyte monocyte progenitor cell head hematopoietic multipotent progenitor cell tail bud vascular endothelium
Stage Range:	20-25 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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