- Title
-
A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration
- Authors
- Maung Ye, S.S., Phng, L.K.
- Source
- Full text @ PLoS Comput. Biol.
Development of the cell-and-plasma 3-D computational fluid dynamics (CFD) model |
Effects of RBC hematocrit and aggregation on viscosity and blood flow velocity. |
Systemic alteration in vessel morphology and blood flow in zebrafish with reduced RBC hematocrit. |
Decrease in ISV diameter exacerbates the decrease in WSS caused by hematocrit reduction. |
Simulation predictions of flow and WSS distribution in networks with ISVs of varying diameters and cross-sectional shapes. (see also |
Hemodynamics adaptation scenarios for Marcksl1 OE and Marcksl1 KO. |
Characterization of RBC flow in Marcksl1 KO zebrafish with reduced vessel diameters. |
Comparison of pressure and WSS distributions in ISVs amongst WT and Marcksl1 network models. |
Hemodynamic alterations arising from network mispatterning in PlxnD1 model (see |
The fundamental components and physics of the cell-and-plasma phase CFD model. |
Grid independence testing for numerical accuracy and precision in the simulations. |