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Phenotype Figure Summary
Marker:
mcu
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Bisbach
et al.
, 2020
Figure 1
mcu
w249a/w249a
brain mitochondrion
mcu
expression absent, abnormal
brain mitochondrion
sdhb
expression absent, abnormal
retina mitochondrion
mcu
expression absent, abnormal
retina mitochondrion
sdhb
expression absent, abnormal
Figure 2
mcu
w249a/w249a
retinal cone cell calcium import into the mitochondrion decreased efficacy, abnormal
Langenbacher
et al.
, 2020
FIGURE 1
mcu
la2434/la2434
cardiac muscle cell calcium atom decreased amount, abnormal
heart
mcu
expression absent, abnormal
heart
mcu
expression decreased amount, abnormal
FIGURE 2
mcu
la2434/la2434
atrium decreased thickness, abnormal
atrium dilated, abnormal
cardiac muscle cell sarcomere broken, abnormal
compact layer of ventricle decreased thickness, abnormal
heart muscle cell broken, abnormal
trabecular layer decreased mass density, abnormal
FIGURE 3
mcu
la2434/la2434
cardiac muscle cell mitochondrion swollen, abnormal
cardiac muscle cell myosin filament disoriented, abnormal
cardiac muscle cell Z disc patchy, abnormal
FIGURE 4
mcu
la2434/la2434
AV node cell action potential disrupted, abnormal
regulation of heart rate by cardiac conduction disrupted, abnormal
FIGURE 5
mcu
la2434/la2434
cardiac conduction disrupted, abnormal
Soman
et al.
, 2019
Fig. 1.
mcu
sh214/sh214
(AB)
brain
mcu
expression decreased amount, abnormal
calcium import into the mitochondrion decreased occurrence, abnormal
head
mcu
expression decreased amount, abnormal
liver
mcu
expression decreased amount, abnormal
whole organism
mcu
expression decreased amount, abnormal
Tomar
et al.
, 2019
Fig. 3
mcu
tpl124/+
, 
mcu
tpl124/tpl124
calcium import into the mitochondrion disrupted, abnormal
caudal fin fat increased amount, abnormal
cell ATP decreased amount, abnormal
dorsal fin subcutaneous fat increased amount, abnormal
whole organism lipid increased amount, abnormal
Soman
et al.
, 2017
Fig. 1
WT + MO3-mcu
whole organism
mcu
expression decreased amount, abnormal
Prudent
et al.
, 2013
Fig. 7
WT + MO1-mcu
actin polymerization or depolymerization process quality, abnormal
anterior/posterior axis specification disrupted, abnormal
cell migration involved in gastrulation disrupted, abnormal
mesodermal cell filamentous actin oriented, abnormal
mitochondrial calcium ion homeostasis disrupted, abnormal
notochord bent, abnormal
regulation of cytosolic calcium ion concentration disrupted, abnormal
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