FIGURE

FIGURE 3

ID

ZDB-FIG-210113-35

Publication

Langenbacher et al., 2020 - Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia

Other Figures

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FIGURE 3

Transmission electron microscopy analysis of MCU mutant ventricles. Representative TEM images of WT (A–C) and MCU(D–F) ventricular cardiomyocytes. (A,D) WT sarcomeres display clear Z-lines (arrows in A) separated by parallel bands of myosin thick filaments. MCU Z-lines are less well defined and patchy (arrows in D) and thick filaments are sometimes disorganized. (B,C) WT myofibrils are closely associated with oval-shaped mitochondria containing tightly packed cristae (arrowheads in B mark examples, C shows more examples). (E,F)MCU myofibrils are also closely associated with mitochondria, but they are less electron-dense and display a round and swollen morphology with more loosely packed cristae [arrowheads in (E) mark examples, (F) shows more examples]. Scale bars indicate 500 nm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mcu^{la2434/la2434}
Observed In:	cardiac muscle cell mitochondrion cardiac muscle cell myosin filament cardiac muscle cell Z disc
Stage:	Adult

Phenotype Detail

Acknowledgments

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