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Phenotype Figure Summary
Marker:
wfs1b
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Crouzier
et al.
, 2022
Figure 1
wfs1b
sa16422/sa16422
(AB)
whole organism
wfs1a
expression decreased amount, abnormal
whole organism
wfs1b
expression decreased amount, abnormal
Figure 3
wfs1b
sa16422/sa16422
(AB)
optomotor response decreased process quality, abnormal
Figure 5
wfs1b
sa16422/sa16422
(AB)
motor neuron increased length, abnormal
Figure 6
wfs1b
sa16422/sa16422
(AB)
whole organism
atf4a
expression decreased amount, abnormal
whole organism
hspa5
expression decreased amount, abnormal
whole organism
xbp1
expression decreased amount, abnormal
Figure 9
wfs1b
sa16422/sa16422
(AB)
whole organism ATP biosynthetic process decreased process quality, abnormal
whole organism cellular respiration decreased process quality, abnormal
Wang
et al.
, 2022
Fig. 6
wfs1b
ah828/+
, 
wfs1b
ah828/ah828
brain endoplasmic reticulum decreased diameter, abnormal
brain endoplasmic reticulum decreased perimeter, abnormal
brain endoplasmic reticulum structure, abnormal
whole organism
atf4a
expression increased amount, abnormal
whole organism
atf6
expression increased amount, abnormal
whole organism
hsp90b1
expression increased amount, abnormal
whole organism
hspa5
expression increased amount, abnormal
Fig. 7
wfs1b
ah828/ah828
; zf206Et
Mauthner neuron axon regeneration decreased process quality, abnormal
Mauthner neuron axon regeneration decreased rate of continuous process, abnormal
whole organism
atf6
expression increased amount, abnormal
whole organism
hsp90b1
expression increased amount, abnormal
whole organism
hspa5
expression increased amount, abnormal
Cairns
et al.
, 2021
Figure 1
wfs1b
sa16422/sa16422
(AB)
head decreased angle to trunk, abnormal
whole organism decreased length, abnormal
Figure 3
wfs1b
sa16422/sa16422
(AB)
motor behavior increased process quality, abnormal
post-vent region motor neuron ab-sv2 labeling spatial pattern, abnormal
post-vent region motor neuron absence of anatomical entity, abnormal
post-vent region motor neuron decreased length, abnormal
thigmotaxis decreased process quality, abnormal
Figure 4
wfs1b
sa16422/sa16422
(AB)
optokinetic behavior decreased process quality, abnormal
retinal ganglion cell decreased amount, abnormal
retinal ganglion cell layer decreased thickness, abnormal
Figure 5
wfs1b
sa16422/+
(AB)
, 
wfs1b
sa16422/sa16422
(AB)
, 
wfs1b
sa16422/sa16422
(AB)
male organism decreased male fertility, abnormal
whole organism dead, abnormal
whole organism decreased fertility, abnormal
whole organism semi-viable, abnormal
whole organism viability, abnormal
O'Hare
et al.
, 2016
Fig. 1
jh1Tg; jh2Tg + MO1-wfs1b
pancreatic B cell decreased area, abnormal
pancreatic B cell mCherry expression decreased distribution, abnormal
Fig. 2
jh1Tg; jh2Tg + MO1-wfs1b
pancreatic B cell decreased amount, abnormal
pancreatic B cell mCherry expression decreased amount, abnormal
Fig. S15
jh1Tg; jh2Tg + MO1-wfs1b
glucose homeostasis disrupted, abnormal
Fig. S8
jh1Tg; jh2Tg + CRISPR3-wfs1b
pancreatic B cell decreased amount, abnormal
pancreatic B cell decreased area, abnormal
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