ZFIN Morpholino: MO1-hey2

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-hey2

Expressed Gene	Anatomy	Figures
efnb2a	caudal artery	Fig. 1 from Esser et al., 2018
ephb2a	(not) dorsal aorta	Fig. 3 from Chou et al., 2010
ephb4a	caudal artery caudal vein plexus	Fig. 2 from Esser et al., 2018
flt4	posterior cardinal vein	Fig. 3 from Chou et al., 2010
hsd3b	interrenal primordium	Fig. 7 from Liu et al., 2006

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Phenotype

Phenotype resulting from MO1-hey2

Phenotype	Fish	Figures
artery absent, abnormal	WT + MO1-hey2	Fig. 3 from Chou et al., 2010
blood circulation absent, abnormal	WT + MO1-hey2	Fig. 3 from Chou et al., 2010
blood vessel morphogenesis disrupted, abnormal	WT + MO1-hey2	Fig. 2 from Herbert et al., 2009
caudal artery efnb2a expression decreased amount, abnormal	y1Tg + MO1-hey2	Fig. 1 from Esser et al., 2018
caudal artery efnb2a expression decreased distribution, abnormal	y1Tg + MO1-hey2	Fig. 1 from Esser et al., 2018

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Phenotype of all Fish created by or utilizing MO1-hey2

Phenotype	Fish	Conditions	Figures
pronephric glomerular capillary absent, abnormal	WT + MO1-hey2	standard conditions	Fig. 3 from Chou et al., 2010
intersegmental vessel absent, abnormal	WT + MO1-hey2	standard conditions	Fig. 3 from Chou et al., 2010
dorsal aorta absent, abnormal	WT + MO1-hey2	standard conditions	Fig. 3 from Chou et al., 2010
artery absent, abnormal	WT + MO1-hey2	standard conditions	Fig. 3 from Chou et al., 2010
blood vessel morphogenesis disrupted, abnormal	WT + MO1-hey2	standard conditions	Fig. 2 from Herbert et al., 2009

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Citations

Include unpublished citations

Esser, J.S., Steiner, R.E., Deckler, M., Schmitt, H., Engert, B., Link, S., Charlet, A., Patterson, C., Bode, C., Zhou, Q., Moser, M. (2018) Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. The FEBS journal. 285(8):1419-1436
Gibb, N., Lazic, S., Yuan, X., Deshwar, A.R., Leslie, M., Wilson, M.D., Scott, I.C. (2018) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development (Cambridge, England). 145(22):
Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2018) Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 8:9840
Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047
Hermkens, D.M., van Impel, A., Urasaki, A., Bussmann, J., Duckers, H.J., Schulte-Merker, S. (2015) Sox7 controls arterial specification in conjunction with hey2 and efnb2 function. Development (Cambridge, England). 142(9):1695-704
Chun, C.Z., Remadevi, I., Schupp, M.O., Samant, G.V., Pramanik, K., Wilkinson, G.A., and Ramchandran, R. (2011) Fli+ etsrp+ Hemato-Vascular Progenitor Cells Proliferate at the Lateral Plate Mesoderm during Vasculogenesis in Zebrafish. PLoS One. 6(2):e14732
Chou, C.W., Hsu, H.C., Quek, S.I., Chan, W.K., and Liu, Y.W. (2010) Arterial and venous vessels are required for modulating developmental relocalization and laterality of the interrenal tissue in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):1995-2004
Rowlinson, J.M., and Gering, M. (2010) Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood. 116(12):2046-2056
Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M., and Stainier, D.Y. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (New York, N.Y.). 326(5950):294-298
Liu, Y.W., and Guo, L. (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Developmental Biology. 297(1):44-58

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