Gene
ephb4a
- ID
- ZDB-GENE-990415-62
- Name
- eph receptor B4a
- Symbol
- ephb4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within convergent extension; ephrin receptor signaling pathway; and vasculature development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Used to study lymphatic system disease. Human ortholog(s) of this gene implicated in central conducting lymphatic anomaly. Orthologous to human EPHB4 (EPH receptor B4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb646 (39 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3378 | Allele with one point mutation | Unknown | Unknown | ENU | |
| hu3445 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ihb537 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb538 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la015774Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025269Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11431 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13275 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30869 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33770 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| central conducting lymphatic anomaly | Alliance | Lymphatic malformation 7 | 617300 |
| Capillary malformation-arteriovenous malformation 2 | 618196 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| lymphatic system disease | y1Tg + MO4-ephb4a | standard conditions | Li et al., 2018 |
| lymphatic system disease | y1Tg + MO2-ephb4a | standard conditions | Li et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001090 | Ephrin receptor ligand binding domain |
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Domain Details Per Protein
| Protein | Length | EPH-B4, SAM domain | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Ephrin type-B receptor 4, ligand binding domain | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class V, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q872
|
986 | ||||||||||||||||||||
|
UniProtKB:O73875
|
987 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ephb4a-201
(1)
|
Ensembl | 2,940 nt | ||
| mRNA |
ephb4a-202
(1)
|
Ensembl | 1,308 nt | ||
| mRNA |
ephb4a-203
(1)
|
Ensembl | 3,056 nt | ||
| mRNA |
ephb4a-204
(1)
|
Ensembl | 2,186 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-264G23 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-1566H6 | ZFIN Curated Data | |
| Contains | STS | unp162 | ||
| Encodes | EST | cb646 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:136748 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171234 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131414 (1) | 3055 nt | ||
| Genomic | GenBank:FO904976 (1) | 34139 nt | ||
| Polypeptide | UniProtKB:O73875 (1) | 987 aa |
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):
- Baek, K.I., Chang, S.S., Chang, C.C., Roustaei, M., Ding, Y., Wang, Y., Chen, J., O'Donnell, R., Chen, H., Ashby, J.W., Xu, X., Mack, J.J., Cavallero, S., Roper, M., Hsiai, T.K. (2022) Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network. Frontiers in cardiovascular medicine. 9:841101
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Chen, J., Li, X., Ni, R., Chen, Q., Yang, Q., He, J., Luo, L. (2021) Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell. 56(22):3115-3127.e6
- Fowler, G., French, D., Rose, A., Squires, P., Anecito da Silva, C., Ohata, S., Okamoto, H., French, C.R. (2021) Protein fucosylation is required for Notch dependent vascular integrity in zebrafish. Developmental Biology. 480:62-68
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Jerafi-Vider, A., Bassi, I., Moshe, N., Tevet, Y., Hen, G., Splittstoesser, D., Shin, M., Lawson, N.D., Yaniv, K. (2021) VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Reports. 35:109255
- Neal, A., Nornes, S., Louphrasitthiphol, P., Sacilotto, N., Preston, M.D., Fleisinger, L., Payne, S., De Val, S. (2021) ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes. Developmental Biology. 473:1-14
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