ZFIN Image: Sam et al., 2020, Fig. 2.

Image

Figure Caption

Fig. 2.

The gata4 mutants are viable to adulthood, but develop an age-dependent cardiomyopathy. (A) Representative western blot showing the absence of Gata4 protein in dissected adult gata4^−/− heart tissue. (B) Quantification by qPCR of gata4/5/6 expression reveals a significant upregulation of gata6 mRNA in gata4^−/− embryos at the 50% epiboly stage. (C–G) Ventricles dissected from adult wild-type fish, representing phenotypically normal hearts. (C′–G′) Similarly dissected hearts from 10-month-old gata4^−/− adults show severe cardiomyopathy and an enlarged ventricular chamber. Scale bar: 1 mm.

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Expression / Labeling details

Phenotype details

Acknowledgments

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