Gene
gata4
- ID
- ZDB-GENE-980526-476
- Name
- GATA binding protein 4
- Symbol
- gata4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; heart morphogenesis; and swim bladder formation. Predicted to be located in nucleus. Is expressed in several structures, including endocrine system; gut; liver and biliary system; mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 87 figures from 68 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh320 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh321 | Allele with one point mutation | Unknown | Unknown | ENU | |
| gata4_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa44950 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa45720 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| wcm5 | Allele with one deletion | Unknown | Unknown | not specified | |
| wcm6 | Allele with one delins | Unknown | Unknown | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| atrial heart septal defect 2 | Alliance | Atrial septal defect 2 | 607941 |
| atrioventricular septal defect | Alliance | Atrioventricular septal defect 4 | 614430 |
| tetralogy of Fallot | Alliance | Tetralogy of Fallot | 187500 |
| ventricular septal defect | Alliance | Ventricular septal defect 1 | 614429 |
| ?Testicular anomalies with or without congenital heart disease | 615542 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GATA-type transcription activator, N-terminal | Transcription factor GATA | Transcription factor GATA-4/5/6 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q09JY7
|
352 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-107C13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131236 (1) | 1142 nt | ||
| Genomic | GenBank:CU207296 (2) | 98771 nt | ||
| Polypeptide | UniProtKB:Q09JY7 (1) | 352 aa |
- Guo, J., Lin, K., Wang, S., He, X., Huang, Z., Zheng, M. (2024) Effects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury. BMC oral health. 24:112112
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Friedman, C.E., Cheetham, S.W., Negi, S., Mills, R.J., Ogawa, M., Redd, M.A., Chiu, H.S., Shen, S., Sun, Y., Mizikovsky, D., Bouveret, R., Chen, X., Voges, H.K., Paterson, S., De Angelis, J.E., Andersen, S.B., Cao, Y., Wu, Y., Jafrani, Y.M.A., Yoon, S., Faulkner, G.J., Smith, K.A., Porrello, E., Harvey, R.P., Hogan, B.M., Nguyen, Q., Zeng, J., Kikuchi, K., Hudson, J.E., Palpant, N.J. (2023) HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell. 59(1):91-107.e6
- Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182
- Jin, Q., Gao, Y., Shuai, S., Chen, Y., Wang, K., Chen, J., Peng, J., Gao, C. (2022) Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification. Journal of genetics and genomics = Yi chuan xue bao. 49(12):1101-1113
- Kong, S., Zhou, D., Fan, Q., Zhao, T., Ren, C., Nie, H. (2022) Salviae miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects against Myocardial Ischemia-Reperfusion Injury and Heart Failure. Computational and Mathematical Methods in Medicine. 2022:7809485
- Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Zagury, J.F., Sieger, D. (2022) Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages. Glia. 70(6):1027-1051
- Ouyang, S., Qin, W.M., Niu, Y.J., Ding, Y.H., Deng, Y. (2022) An EGFP Knock-in Zebrafish Experimental Model Used in Evaluation of the Amantadine Drug Safety During Early Cardiogenesis. Frontiers in cardiovascular medicine. 9:839166
- Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
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