Gene
alg13
- ID
- ZDB-GENE-060307-1
- Name
- ALG13 UDP-N-acetylglucosaminyltransferase subunit
- Symbol
- alg13 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within dorsal/ventral pattern formation. Is expressed in blastodisc; ovary; unfertilized egg; and yolk. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to human ALG13 (ALG13 UDP-N-acetylglucosaminyltransferase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tse et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23993 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 36 | Alliance | Developmental and epileptic encephalopathy 36 | 300884 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13, OTU domain | OTU domain | Papain-like cysteine peptidase superfamily | Tudor domain |
|---|---|---|---|---|---|
|
UniProtKB:E9QIU2
|
889 | ||||
|
UniProtKB:A0A0R4IPL2
|
854 | ||||
|
UniProtKB:Q49HH8
|
859 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-117J3 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-81E1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158505 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001031838 (1) | 2854 nt | ||
| Genomic | GenBank:BX510996 (1) | 197012 nt | ||
| Polypeptide | UniProtKB:E9QIU2 (1) | 889 aa |
- Wilson, M.L., Romano, S.N., Khatri, N., Aharon, D., Liu, Y., Kaufman, O.H., Draper, B.W., Marlow, F.L. (2024) Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature communications. 15:52485248
- Yue, M.J., Mo, S.J., Song, P., and Gong, Y.Z. (2011) Identification of Z-OTU protein during zebrafish oogenesis and early embryogenesis. Dong wu xue yan jiu = Zoological research. 32(4):386-390
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Mo, S., Song, P., Lv, D., Chen, Y., Zhou, W., Gong, W., and Zhu, Z. (2005) Zebrafish z-otu, a novel Otu and Tudor domain-containing gene, is expressed in early stages of oogenesis and embryogenesis. BBA Gene Structure and Expression. 1732(1-3):1-7
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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