FIGURE

Fig. 4

ID

ZDB-FIG-240715-64

Publication

Banerjee et al., 2024 - Hypomyelinated vps16 Mutant Zebrafish Exhibit Systemic and Neurodevelopmental Pathologies

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Fig. 4

vps16(-/-) mutants show normal distance traveled at 5 dpf and significantly reduced distance traveled at 7 dpf in response to alternating cycles of light and dark. (A) Representative heatmap images of total distance moved by individual vps16(-/-) larvae at 5 dpf (mutants = top two rows, siblings = bottom two rows) during 3 min period of light and dark. (B) Graph representing average distance traveled by vps16(-/-) larvae at 5 dpf in 4 alternating light/dark cycles of 3 min each (siblings in blue; mutants in green). (C) Graph representing average distance traveled by siblings (blue, n = 71) and vps16(-/-) (green, n = 72) in light and dark periods. (D) Graph representing average velocity of siblings (blue, n = 71) and vps16(-/-) (green, n = 72) in light and dark periods. (E) Representative heatmap images of total distance moved by individual vps16(-/-) larvae at 7 dpf (mutants = top two rows; siblings = bottom two rows) during 3 min period of light and dark. (F) Graph representing average distance traveled by vps16(-/-) larvae at 7 dpf in 4 alternating light/dark cycles of 3 min each (siblings in blue; mutants in green). (G) Graph representing average distance traveled by siblings (blue, n = 72) and vps16(-/-) (green, n = 72) in light and dark periods. (H) Graph representing average velocity of siblings (blue, n = 72) and vps16(-/-) (green, n = 72) in light and dark periods. For all graphs, “N.S.” = not significant, “***” = p < 0.001, “****” = p < 0.0001, and error bars indicate SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vps16^wsu4/wsu4 (AB)
Observed In:	swimming behavior
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.