FIGURE

Figure 2

ID

ZDB-FIG-240214-2

Publication

Witkamp et al., 2024 - Lithium: effects in animal models of vanishing white matter are not promising

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Figure 2

Lithium improves motor deficits in mutant eif2b5^zc103/zc103 zebrafish. WT (circles) and eif2b5^zc103/zc103 (VWM; squares) zebrafish were treated with placebo (black; WT: n = 48, VWM: n = 38) or 1 mM lithium (blue; WT: n = 12, VWM: n = 26) and assessed on distance moved, moving time, and velocity at 7 dpf. The graphs show individual and mean values, +/− SEM. The shown motor behavior parameters differ significantly in placebo-treated WT versus placebo-treated eif2b5^zc103/zc103 zebrafish (p < 0.0001; not indicated, Supplementary Data Sheet S1). Treatment effects were statistically analyzed using an unpaired t-test or Mann–Whitney test (VWM, distance moved; Supplementary Data Sheet S1). *p < 0.05 and **p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eif2b5^zc103/zc103
Condition:	chemical treatment by environment: lithium chloride
Observed In:	swimming
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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