Figure 7—figure supplement 4.

RNAseq analysis shows dynamic transcriptional profiles of macrophages upon Salmonella infection.

Tg(mfap4:mCherry-F/tnfa:GFP-F) larvae were either infected with Salmonella (Sal-INF) or non-infected (Non-INF) before doing RNA sequencing, as described in Figure 7A. (A) Venn diagram showing intersecting up- or down-regulated genes (indicated as Up and Down, respectively) upon infection from macrophage transcriptomes at 4 hpi and 4 dpi. The numbers of up- and down-regulated genes are indicated in bold in each unique and overlapping sector of the Venn diagram. The most noteworthy genes of each overlapping sector of the Venn diagram are indicated (p-adj <0.05|(log₂(FC) ≥ or ≤1)). (B) Chart representation of enriched GO terms in up-regulated genes upon infection at 4 hpi (p-adj <0.05|log₂(FC) ≥1). (C) Chart representation of enriched GO terms in up-regulated genes upon infection at 4 dpi (p-adj <0.05|(log₂(FC) ≥0.1)). Graph shows the fold enrichment, red color: lowest enrichment false discovery rate (FDR) and blue color: highest enrichment FDR.