FIGURE

Fig. 6

ID

ZDB-FIG-240130-53

Publication

Kozol et al., 2023 - Drugs prescribed for Phelan-McDermid syndrome differentially impact sensory behaviors in shank3 zebrafish models

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Fig. 6

MPEP exposed wildtype larvae exhibit hyporeactivity and hypoactivity during lights-off conditions. a) Activity during the first 30 seconds of lights-off of larvae exposed to 5 μM MPEP. b) Activity during the full 5 minutes lights-off of larvae exposed to 5 μM MPEP. Box plots represent 25th and 75th percentile, and median, with min to max whiskers. Sample Sizes, WT = 23, WT + MPEP = 24, shank3ab N = 33, shank3ab N + MPEP = 31, shank3ab C = 19, and shank3ab C + MPEP= 24. p values; * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001.

Expression Data

Expression Detail

No data available

Antibody Labeling

No data available

Phenotype Data

Fish:	AB/TL shank3a^{umi101/umi101}; shank3b^{umi102/umi102} (AB/TL) shank3a^{zf3839/zf3839}; shank3b^{zf3840/zf3840} (AB/TL)
Conditions:	chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine lighting conditions
Observed In:	swimming behavior visual behavior
Stage:	Day 6

Phenotype Detail

Acknowledgments

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