| Name: |
2-methyl-6-(phenylethynyl)pyridine |
| Synonyms: |
2-methyl-6-(phenylethynyl)pyridine,
6-Methyl-2-(phenylethynyl)pyridine,
MPEP
|
| Definition: |
A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. |
| Ontology: |
ChEBI [CHEBI:64159]
(
EBI
)
|