FIGURE

Fig. 2

ID

ZDB-FIG-231208-28

Publication

Celeghin et al., 2023 - A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes

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Fig. 2

Detection of cardiac dilation and inflammation in zebrafish Dsp mutants.

A–A′-A″ Heart morphology analysis of wild type and -ab mutant zebrafish embryos using a myocardial-specific transgene Tg(tg:EGFP-myl7:EGFP)^ia300 identified a global dilation of both chambers in -ab mutants. All embryos are at 3 dpf, in lateral view. Sample size: n = 22 ± 1. R.R relative ratio. Error bars: SEM. ****p < 0.0001. Test: Unpaired t-test. B–B′–B″: Cells expressing the inflammatory marker L-plastin are more abundant in -ab mutants, compared to WT. All embryos are at 3 dpf, in lateral view, anterior to the left. Sample size: n = 6. R.I. relative intensity. Error bars: SEM. **p < 0.01. Test: Unpaired t-test.

Expression Data

Antibody:	Ab8-lcp1
Fish:	WT dspa^sa13356/+; dspb^ia303/+
Anatomical Term:	heart
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dspa^sa13356/+; dspb^ia303/+ dspa^sa13356/+; dspb^ia303/+; ia300Tg
Observed In:	heart leukocyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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